Time course of physical and psychological responses to selegiline monotherapy in newly diagnosed, idiopathic parkinosonism
Identifieur interne : 002126 ( Main/Exploration ); précédent : 002125; suivant : 002127Time course of physical and psychological responses to selegiline monotherapy in newly diagnosed, idiopathic parkinosonism
Auteurs : C. Kirollos ; A. Charlett ; S. G. Bowes ; A. G. Purkiss ; C. J. A. O Eill ; C. Weller ; J. Dickins ; G. Faulkner ; P. W. Nicholson ; W. B. Hunt ; R. J. Dobbs ; S. M. DobbsSource :
- European Journal of Clinical Pharmacology [ 0031-6970 ] ; 1996-04-01.
Abstract
Abstract.: Rationale: Poor specificity of face-value endpoints and the poor sensitivity of gross clinical examination may have militated against demonstrating prophylaxis by selegiline. Methods: Objective measures of the four cardinal signs were used as primary outcome criteria in a randomised, double-blind, placebo-controlled, parallel group study of selegiline monotherapy in 25 newly diagnosed elderly sufferers from idiopathic parkinsonism, stratified for sex and Hoehn and Yahr functional staging. Results: There was a significant interaction between time and nature of treatment with respect to rigidity. The effect of time during active treatment was highly significant: rigidity decreased by 1.3 % per week. The worsening of rigidity on placebo was not statistically significant. Neuronal rescue is a possible explanation for the long term, progressive improvement produced by selegiline. No significant treatment effect was seen on the other cardinal signs. However, there was a significant quadratic time trend for arousal on active treatment suggesting tolerance to this effect. Conclusion: The difference in time course between the psychostimulant and physical effects suggests more than one mode of action.
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DOI: 10.1007/s002280050062
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Methods: Objective measures of the four cardinal signs were used as primary outcome criteria in a randomised, double-blind, placebo-controlled, parallel group study of selegiline monotherapy in 25 newly diagnosed elderly sufferers from idiopathic parkinsonism, stratified for sex and Hoehn and Yahr functional staging. Results: There was a significant interaction between time and nature of treatment with respect to rigidity. The effect of time during active treatment was highly significant: rigidity decreased by 1.3 % per week. The worsening of rigidity on placebo was not statistically significant. Neuronal rescue is a possible explanation for the long term, progressive improvement produced by selegiline. No significant treatment effect was seen on the other cardinal signs. However, there was a significant quadratic time trend for arousal on active treatment suggesting tolerance to this effect. 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